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2020 Fiscal Year Final Research Report

Elucidation of structure and function of mitochondrial voltage-dependent anion channel using the interacting molecules

Research Project

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Project/Area Number 17K08296
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kimura-Someya Tomomi  国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (80450401)

Project Period (FY) 2017-04-01 – 2021-03-31
Keywords無細胞タンパク質合成 / イオンチャネル
Outline of Final Research Achievements

Voltage-dependent anion channel 1 (VDAC1), which is located in the outer mitochondrial membrane, plays important roles in various cellular processes. We determined high-resolution crystal structures of heptameric human VDAC1 prepared by using a cell-free protein synthesis system, which avoided the need for denaturation and refolding of the protein. We also tried to determine the structure of VDAC1 complexed with the interacting compound.

Free Research Field

膜タンパク質生化学

Academic Significance and Societal Importance of the Research Achievements

正しく折りたたまれたVDACの構造は、生体内での構造を反映していると考えられた。この構造に基づき、VDACに作用する化合物を設計したり、既存の相互作用化合物の最適化を行ったりすることで、VDACの関与が指摘されている疾患である、がんや神経変性疾患に対する治療薬の開発に繋がると考えられる。

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Published: 2022-01-27  

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