Exploring factors that influence the response to antidepressant augmentation therapy

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: Inoue Kazuyuki 静岡県立大学, 薬学部, 准教授 (90514589)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: うつ病 / 抗うつ薬 / 増強療法

Outline of Final Research Achievements

Patients with depression who do not exhibit a response to existing antidepressants require treatment with antidepressant augmentation therapy with a combination of mood stabilizers and/or atypical antipsychotics. Because of differences in drug combination and dosage among patients, the factors that influence the drug response and/or the occurrence of side effects in antidepressant augmentation therapy have hardly been studied. We examined factors influencing the drug response and occurrence of side effects in antidepressant treatment including augmentation therapy. The findings of this study can be useful for research on antidepressant augmentation therapy in the future.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

本研究では、抗うつ薬増強療法を含めた抗うつ薬治療における効果、副作用発現、およびうつ症状に関わる因子について探索し、いくつかの可能性が示唆される因子を見いだした。本研究で得られた知見は、今後、抗うつ薬増強療法に関する更なる研究を遂行する上で、有益な情報を提供し、更に詳細な検討を行い、臨床現場に提供することで、難治性うつ病患者における抗うつ薬増強療法の個別化医療へ繋がると考えられる。