Application of human iPS cell-derived intestinal epithelial cells as a novel prediction system for drug disposition and drug interaction

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: Iwao Takahiro 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 (50581740)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 小腸 / 薬物動態 / iPS細胞

Outline of Final Research Achievements

We were able to find some useful small molecule compounds in the differentiation of human iPS cells to intestinal epithelial cells in this study. It was indicated that the human iPS cell-derived intestinal epithelial cells had drug metabolizing enzyme activities, CYP3A4 inducibility, drug transporter activities, and barrier functions. In addition, it was suggested that the cells would be available as an evaluation system to predict intestinal drug absorption quantitatively.

Free Research Field

薬物動態学

Academic Significance and Societal Importance of the Research Achievements

本研究では、ヒトiPS細胞から作製した腸管上皮細胞が医薬品の消化管吸収を定量的に評価できる系としての有用性を示すことができた。現在、よりよい医薬品の消化管吸収予測系の開発が望まれていることから、本研究で得られた成果はこの分野において有用であると考えられる。