2019 Fiscal Year Final Research Report
Studing the mechanism of synaptic plasticity
| Project/Area Number |
17K08541
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Keywords | グルタミン酸受容体 / シナプス可塑性 / 糖鎖修飾 |
|---|
| Outline of Final Research Achievements |
AMPA type glutamate receptors (AMPA-R) are mainly playing in the expression of synaptic plasticity. We have been analyzing the involvement of protein modification of AMPA-R in neuronal functions. Especially we focus on N-glycosylation of AMPA-R extracellular domain. The occupancy of AMPA-R glycosylation is regulated in activity dependent manner and it regulates synaptic plasticity. Based on our results we generated knock-in mice in which the glycosylation site is modified. And we are performing elecrtophyilogical and behavioral analysis using these mice.
|
| Free Research Field |
神経科学
|
| Academic Significance and Societal Importance of the Research Achievements |
脳の主たる興奮性神経伝達機構であるグルタミン酸とその受容体であるグルタミン酸受容体の糖鎖修飾がどのように神経機能を制御しているか、その詳細はわかっていなかった。本研究により主たるりグルタミン酸受容体であるAMPA型グルタミン酸受容体の糖鎖修飾による機能調節機能が明らかとなり、それに基づくモデルマウスの作成・解析により学習・記憶や各種精神疾患への関与が明らかとなりつつある。
|
