Role of NOX1/NADPH oxidase in acquired immunity

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K08601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Matsumoto Misaki 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80533926)
• Co-Investigator(Kenkyū-buntansha): 岩田 和実 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60305571)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 活性酸素種 / 免疫 / 関節炎 / 喘息

Outline of Final Research Achievements

NOX1 mRNA were expressed in splenic B cells, T cells and CD11b+ monocytes/macrophages. No significant differences were observed in antibody production or in ovalbumin (OVA)-induced asthma between wild-type mice (WT) and Nox1-KO. However, the severity and incidence of experimental collagen-induced arthritis (CIA) following the administration of a low dose of endotoxin (LPS) were significantly lower in Nox1-KO. These results indicate an as yet unidentified role for NOX1 in immune responses.

Free Research Field

病態分子薬理学

Academic Significance and Societal Importance of the Research Achievements

免疫応答におけるNOX2 (gp91phox)の重要性はこれまでに詳細に研究されてきたが、免疫応答とNOX1アイソフォームの連関は不明である。本研究の成果は、これまで未知であったNOX1と免疫応答のクロストークを示唆するものであり、関節炎リウマチの発症機序の解明および新しい治療標的の開拓に資するものと思われる。