2019 Fiscal Year Final Research Report
The significance of host immune status and microRNA abnormalities in EBV-associated tumor
| Project/Area Number |
17K08716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | EBウイルス / microRNA / 潜伏感染遺伝子 |
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| Outline of Final Research Achievements |
To explore the significance of immune host status during EBV-associated oncogenesis, analyses of EBV-microRNAs expression, latent gene expression and EBV copy number were performed using 90 cases of EBV-related tumors. EBV-microRNA expression and copy numbers were high in the relatively immunocompetent hosts. In addition, EBV-microRNA expression was higher in lymphoproliferative disorders than in monomorphic malignant lymphomas, suggesting the significance of EBV-microRNA in early stage of oncogenesis.
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| Free Research Field |
病理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究ではEBVに関連した上皮性あるいはリンパ球性の腫瘍発生の過程において，比較的早期の段階からEBV由来のmicroRNAの発現が重要であることを明らかにした．高齢化や移植医療の発達などにより，潜在的な免疫不全状態の患者が増加し，これに伴ってEBVに関連した腫瘍発生が増加することが予想される．本研究がEBVに関連した腫瘍発生の機序の一端を明らかにすることにより，診断や治療における有益な情報となる可能性がある．
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