2019 Fiscal Year Final Research Report
Functional analysis of autophagy in gastric carcinogenesis and its application to prevention
| Project/Area Number |
17K09348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Fukui |
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Principal Investigator |
OHTANI MASAHIRO 福井大学, 学術研究院医学系部門(附属病院部), 講師 (20372500)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | ヘリコバクターピロリ菌 / オートファジー |
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| Outline of Final Research Achievements |
We investigated the effect of autophagy on inflammatory gastric carcinogenesis caused by Helicobacter pylori (HP) infection. HP-infected gastrin transgenic mice (INS-GAS mice) had histopathologically significant gastritis and dysplasia 28 weeks after infection. The expression of ATG5 and Beclin-1 was examined by immunohistochemistry, and both were expressed in the glandular epithelial cells of the gastric mucosal tissue, and HP-infected mice were diffuse and higher than non-infected mice. These results indicate that HP infection causes severe dysplasia in INS-GAS mice, and that autophagy is strongly induced over time due to persistent infection.
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| Free Research Field |
消化器内科
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| Academic Significance and Societal Importance of the Research Achievements |
オートファジーは細胞内分解機構の一つであり、細胞の恒常性の維持において主要な役割を果たしている。癌、感染症等様々な疾患や病態へ関与が報告され、癌細胞に対しては腫瘍抑制・促進の両方の作用を有していることが明らかにされ、治療応用への試みも行われてきている。今回の胃発癌マウスモデルを用いた検討では、オートファジーは炎症性胃発癌機序に関与している可能性が示された。さらなる検討により新たな治療法へのアプローチが期待される。
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