epidermal fatty acid binding protein(FABP) in Peyer's patch: a contribution to intesitnal flora control

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09368
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Akita University
• Principal Investigator: SUZUKI Ryoji 秋田大学, 医学系研究科, 准教授 (20396550)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 脂肪酸結合タンパク質 / パイエル板 / Ｍ細胞 / 樹状細胞 / 腸内細菌叢

Outline of Final Research Achievements

epidermal fatty acid binding protein (EFABP) expression cells in Peyer's patch have S100 protein phagocytosis capability. M cells in epithelium and dendritic cells(DCs) express EFABP. DC could penetrate S100 positive border with 4cCorporation of EFABP positive M cell and DC, which would work as antigen presenting switch. EFABP positive germinal center macrophage secrete AnnexinV. AnnexinV expose phosphatidylserine to the surface of surrounding B220 positive cells. This process enhances macrophage phagocytosis of B220 positive cells. Which might work as antigen specific IgA production through B cell selection.

Free Research Field

解剖学

Academic Significance and Societal Importance of the Research Achievements

腸内細菌叢を構成する細菌選択機構の一端をパイエル板における表皮型脂肪酸結合タンパク質の担う仕組みで具体的に説明した。
表皮型脂肪酸結合タンパク質は長鎖脂肪酸と結合してシグナリング分子として機能することが分かっているので、今後腸内細菌叢を操作する方法として脂肪酸の経口投与の可能性を示せた。