2019 Fiscal Year Final Research Report
Elucidation of bioactive lipid mediators related to ischemia-reperfusion injury and development of novel treatment strategy
| Project/Area Number |
17K09579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 虚血再灌流傷害 / 脂質メディエーター |
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| Outline of Final Research Achievements |
Ischemia-reperfusion injury remains unsolved critical issue which lacks any specific prevention and treatment under the era of development in revascularization. Here, we found novel disease mechanisms of ischemia-reperfusion injury by comprehensively analyzing bioactive lipid metabolites (lipid mediators), which we have developed as LC/MS/MS system-based metabololipidomics. These findings unveil a detailed pathological mechanism of ischemia-reperfusion organ injury and suggest a novel therapeutic approach.
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| Free Research Field |
脂質生化学
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| Academic Significance and Societal Importance of the Research Achievements |
虚血再灌流傷害は、現在の医学では特異的な予防法・治療法が存在せず、臨床現場における重要な課題である。動脈硬化性疾患に由来する心筋梗塞や脳梗塞、さらには臓器移植におけるドナー臓器等では、虚血再灌流に陥った臓器そのものの傷害が生じる。また大血管手術・整形外科手術ならびに災害によって四肢末梢の広範な虚血が生じた場合、再灌流によって肺・腎臓・脳・肝臓等の遠隔臓器に深刻な臓器傷害を生じることが知られている。虚血再灌流傷害を新たな視点から見直し、新しい病態メカニズムを理解したうえで、新規の特異的予防法・治療法を確立することが強く求められている。
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