2019 Fiscal Year Annual Research Report
Analysis of oral and intestinal flora related with development or progression of IgA nephropathy
Project/Area Number |
17K09721
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Research Institution | Hyogo Medical University |
Principal Investigator |
長澤 康行 兵庫医科大学, 医学部, 講師 (10379167)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
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Keywords | IgA腎症 / 齲蝕菌 / 歯周病菌 / ミュータンス菌 / C.Rectus / 扁桃 |
Outline of Annual Research Achievements |
IgA腎症患者において口腔内の病原性のある細菌であるミュータンス菌(いわゆる虫歯菌)の中でも病原性の高いCnmを発現しているものが、IgA腎症患者の扁桃でも検出されることを論文として報告した(Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy.Ito S, Misaki T, Naka S, Wato K, Nagasawa Y, Nomura R, Otsugu M, Matsumoto-Nakano M, Nakano K, Kumagai H, Oshima N. Sci Rep. 2019 Dec 27;9(1):20130.)また、IgA腎症患者において治療効果が高い群についても臨床的に解析し論文として報告した(Efficacy of corticosteroid therapy for IgA nephropathy patients stratified by kidney function and proteinuria Yasuyuki Nagasawa, Ryohei Yamamoto, Maki Shinzawa, Tatsuya Shoji, MD, Yukiko Hasuike, Katsuyuki Nagatoya, Atsushi Yamauchi, MD, Terumasa Hayashi, Takayuki Kuragano, Toshiki Moriyama, Yoshitaka Isaka Clinical and Experimental Nephrology in press)さらに歯周病菌についてのモデルも確立し現在論文準備中である。
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Research Products
(2 results)
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[Journal Article] Efficacy of corticosteroid therapy for IgA nephropathy patients stratified by kidney function and proteinuria2020
Author(s)
Yasuyuki Nagasawa, Ryohei Yamamoto, Maki Shinzawa, Tatsuya Shoji, MD, Yukiko Hasuike, Katsuyuki Nagatoya, Atsushi Yamauchi, MD, Terumasa Hayashi, Takayuki Kuragano, Toshiki Moriyama, Yoshitaka Isaka
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Journal Title
Clinical and Experimental Nephrology
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access
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[Journal Article] Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy.2019
Author(s)
Ito S, Misaki T, Naka S, Wato K, Nagasawa Y, Nomura R, Otsugu M, Matsumoto-Nakano M, Nakano K, Kumagai H, Oshima N
-
Journal Title
Scientific Reports
Volume: 9(1)
Pages: -
DOI
Peer Reviewed / Open Access