2019 Fiscal Year Final Research Report
Analysis of oral and intestinal flora related with development or progression of IgA nephropathy
Project/Area Number |
17K09721
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Hyogo Medical University |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Keywords | IgA腎症 / 歯周病菌 / 齲蝕菌 / 扁桃 / 口腔内細菌 |
Outline of Final Research Achievements |
We reported that Cnm(+)-mutans was highly detected in tonsils of IgA nephropathy patients as article(Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy.Ito S, Misaki T, Naka S, Wato K, Nagasawa Y, Nomura R, Otsugu M, Matsumoto-Nakano M, Nakano K, Kumagai H, Oshima N. Sci Rep. 2019 Dec 27;9(1):20130.).And we repotted that efficacy of corticosteroid therapy for IgA nephropathy patients stratified by kidney function and proteinuria as article (Efficacy of corticosteroid therapy for IgA nephropathy patients stratified by kidney function and proteinuria Yasuyuki Nagasawa, Ryohei Yamamoto, Maki Shinzawa, Tatsuya Shoji, MD, Yukiko Hasuike, Katsuyuki Nagatoya, Atsushi Yamauchi, MD, Terumasa Hayashi, Takayuki Kuragano, Toshiki Moriyama, Yoshitaka Isaka Clinical and Experimental Nephrology 2020, in press). Moreover, we built up the IgA nephropathy model mise induced by administration of periodontal bacteria.
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Free Research Field |
腎臓内科
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Academic Significance and Societal Importance of the Research Achievements |
IgA腎症は透析導入の主要な原疾患の一つである。この発症に歯周病菌や齲蝕菌が深くかかわっていることを明らかにすることにより、IgA腎症の発症機序に新たな視点を確立した。近年、歯周病菌や齲蝕菌が多くの疾患の発症や増悪に関わっていることが明らかになってきており、IgA腎症もその中の一つとして考えることができることを確立した。また、このことが新たな治療ターゲットとなり、将来的な透析医療を抑制することが期待される。
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