Ion channel dysfunction and small molecule homeostasis dysregulation in amyotrophic lateral sclerosis

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Fukushima Medical University (2018-2019); Juntendo University (2017)
• Principal Investigator: Kanai Kazuaki 福島県立医科大学, 医学部, 教授 (10375751)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 筋萎縮性側索硬化症

Outline of Final Research Achievements

In patients with amyotrophic lateral sclerosis, we investigated the association between motor axonal excitability abnormality and small molecule expression dysregulation in biological fluids. We divided the patients into two groups (a high value group and a low value group) on the basis of neurophysiological indices that are associated with prognosis. As results, we found several small molecules that were correlated with neurophysiological indices that are associated with prognosis.

Free Research Field

臨床神経生理学

Academic Significance and Societal Importance of the Research Achievements

これまでもALSにおける有力な病態仮説であったグルタミン酸興奮毒性仮説を説明し得る結果が得られた。またALSにおける新規治療法開発における有力なサロゲートマーカーとなる可能性が示唆され、今後の治療法開発に役立つ可能性が示された。