Role of integrated stress response in adipocyte

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K09862
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: The University of Tokushima
• Principal Investigator: MIYAKE Masato 徳島大学, 先端酵素学研究所(プロテオ), 講師 (30588976)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 肥満 / 糖尿病 / 臓器連関 / 摂食調節

Outline of Final Research Achievements

In this study, we investigated the role of integrated stress response (ISR), which is one of stress response signaling and activated in metabolic disorders, in adipocytes of mice. The ISR did not affect metabolic function in adipocyte. However, activation of the ISR induced GDF15 expression that is known to repress appetite in adipocyte. The ISR-induced GDF15 repressed high-fat diet specific food intake and improved diet-induced obesity.

Free Research Field

代謝学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果によって統合的ストレス応答の活性化は、細胞自律的なストレスへの対応の役割だけでなく、内分泌ホルモンなどを介した臓器連関によって個体レベルでストレスに応答して恒常性を保つために機能していることが示唆された。また、脂肪細胞への適切な統合的ストレス応答の活性化は、摂食行動を制御する可能性が示され新たな肥満や糖尿病の治療標的となることがわかった。