Functional analysis of circ/miRNA in malignant lymphoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K09914
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Akita University
• Principal Investigator: TAGAWA HIROYUKI 秋田大学, 医学系研究科, 非常勤講師 (30373492)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: circRNA / malignant lymphoma

Outline of Final Research Achievements

Circular RNA is a circular non-coding RNA that adsorbs miRNA to complementary sequences and causes abnormal expression. We identified several circRNA candidates required for tumor cell maintenance, examined changes in their downstream miRNAs, and identified circ-MTO1 as a circRNA whose expression is reduced in B-cell lymphoma. circ-MTO1 adsorbs the oncogenes miR-17 and miR-20. Therefore, It was speculated that the decreased expression of the circRNA causes an abnormal increase in the expression of miR-17 and miR-20, with the expression of the tumor suppressor gene PTEN, which is the target protein of these miRNAs.

Free Research Field

造血器腫瘍

Academic Significance and Societal Importance of the Research Achievements

我々の研究はcircRNAのがん生物学的な意義を初めて明らかにする試みであり、がんとcircRNAに関する新分野を開拓できる。そのことにより従来の解析法では一部未知であったリンパ腫をはじめとするがんの病態解明に大きな前進を与える。本研究課題は、新しい治療法や診断法の開発のシーズとして産業的、経済的に大きな潜在性を有しており、また機序の解明は社会的に大きなインパクトを与えることができる。