The analysis about the new epithelial-mesenchymal crosstalk using hereditary hypertrichosis-derived papilla cells.

2023 Fiscal Year Final Research Report

• Project/Area Number: 17K10211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kochi University
• Principal Investigator: OHKO KENTARO 高知大学, 教育研究部医療学系臨床医学部門, 助教 (90595274)
• Co-Investigator(Kenkyū-buntansha): 中島 喜美子 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (20403892) ; 佐野 栄紀 高知大学, 医学部, 特任教授 (80273621)
• Project Period (FY): 2022-11-15 – 2024-03-31
• Keywords: 多毛症 / Cantu症候群 / 毛乳頭細胞 / SUR2B遺伝子 / Minoxidil / 発毛 / Dermal papillae

Outline of Final Research Achievements

Hair is found on the entire body, except for the palms, and is classified into two categories: hard hair, such as head, eyebrows, and axillary hair, and soft hair, which is found on many other parts of the skin. In this study, we analyzed the signals leading to hypertrichosis in mesenchymal cells using papilla cells from patients with Cantu syndrome, an inherited form of hypertrichosis, to clarify the true nature of the disorder. We also analyzed the genes and proteins expressed by these cells comprehensively. In addition, we confirmed that the expression of hair growth-related proteins was observed when the established hair papilla cell culture system was treated with a known hair growth stimulator.

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Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

本研究により、Cantu症候群の多毛における分子動態が明らかにされた。加えて、本研究の成果は、新規発毛剤のシーズにもなりうると考えられた。