Analysis of regional respiratory movement in interstitial pneumonia on dynamic-ventilation computed tomoraphy

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10361
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Yukihiro Nagatani 滋賀医科大学, 医学部, 特任助教 (80402725)
• Co-Investigator(Kenkyū-buntansha): 山城 恒雄 琉球大学, 医学部附属病院, 講師 (30772545) ; 大谷 秀司 滋賀医科大学, 医学部, 助教 (70510270)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 呼吸ダイナミックCT / 間質性肺炎 / 局所呼吸運動 / 超低線量CT

Outline of Final Research Achievements

Respiratory coordinate between subpleural and central regions in measured values derived from dynamic-ventilation computed tomography was demonstrated to be reduced in patients with idiopathic pulmonary fibrosis, which fibrosis in secondary lobule is predominant in periphery, as compared with connective tissue disease associated interstitial pneumonia. This result indicates that invisible early-staged pulmonary fibrosis can be detected through regional analyses of dynamic-ventilation computed tomography data in normal-appearing area.

Free Research Field

放射線診断学

Academic Significance and Societal Importance of the Research Achievements

今研究において、4次元呼吸ダイナミックCT画像データの呼吸内の局所変動を解析することで、従来の呼吸機能検査等では、検出できなかった早期の肺野線維化病変を検出する可能性があることを示せたことは、間質性肺炎の診断や治療に関して、より適切な時期により効果的な介入が、将来的に可能となることを示唆しており、意義深い。