2022 Fiscal Year Final Research Report

Research of conservative breast cancer treatment using calcium phosphate cement paste marker

Research Project

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Project/Area Number	17K10487
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Yokohama City University
Principal Investigator	Ogino Ichiro 横浜市立大学, 附属市民総合医療センター, 准教授 (20275035)
Co-Investigator(Kenkyū-buntansha)	稲山嘉明横浜市立大学, 附属市民総合医療センター, 教授 (10184730) 成井一隆横浜市立大学, 附属市民総合医療センター, 講師 (70468172) 幡多政治横浜市立大学, 医学研究科, 教授 (60285145)
Project Period (FY)	2017-04-01 – 2023-03-31
Keywords	乳がん / マーカー / 放射線治療 / リン酸カルシウム
Outline of Final Research Achievements	From May 24, 2019, to March 14, 2023, a randomized comparative trial (jRCTs 032180042) was conducted on post-chemotherapy breast-conserving therapy with the insertion of CPCM (Calcium phosphate cement marker). A total of 16 participants were enrolled, with 6 in the CPCM insertion group. Among them, 10 underwent breast-conserving therapy, 3 underwent total mastectomy, and 3 were undergoing chemotherapy. Among the 3 cases of breast-conserving therapy, CPCM was injected in 3 cases, making them the intervention group, while 7 cases formed the control group. Among the 3 cases with CPCM injection, 2 achieved pathological complete response (pCR), and the excised breast specimen volumes were 65g and 38g, respectively. Among the 7 cases in the control group, 1 achieved pCR, and the excised breast specimen volume was 37g. Due to the impact of the coronavirus, this trial is still ongoing, and it is expected to take some time before the results are available.
Free Research Field	放射線治療
Academic Significance and Societal Importance of the Research Achievements	リン酸カルシウムセメントペーストを原発腫瘍に注入すると、化療後に腫瘍が著明に縮小しても腫瘍の位置が同定できる。このため、切除範囲を縮小でき、乳房形態温存を十分配慮した乳房温存療法が可能となる。また、リン酸カルシウムは歯や骨に存在するハイドロキシアパタイトであり生体との反応がない物質である。そのため、乳房形態温存を十分配慮した乳房温存療法が証明できなくても、他の画像誘導放射線治療への発展やラジオ波熱焼灼療法と放射線治療を用いた非切除治療などの発展が期待できるマーカーとなる。