CT detection of primary and metastatic tumor and their treatment abscopal effect via radiation

2023 Fiscal Year Final Research Report

• Project/Area Number: 17K10489
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: Harada Satoshi 岩手医科大学, 医学部, 講師 (20244931)
• Project Period (FY): 2017-04-01 – 2024-03-31
• Keywords: Radiation / Durg Delivery System / Particle imaging / microprobe imaging / immunotherapy

Outline of Final Research Achievements

We aimed to image and treat the primary tumor by immunogenic cell death (ICD), and metastatic treatment through abscopal effect using particles that release liposome-protamine-hyaluronic acid nanoparticles (LPH-NP) in response to radiation, in two radiation sessions.
The accumulation of particles via antigen-antibody of VEGRF1/2 allowed us to image Primary tumor and metastases. First radiation localized anti-CD47 si-RNA, anti-PD-L1-Ab and P-selectin. Second radiation session localized HMGB-1, ATP, and anti-CD47 si-RNA. These treatments facilitated attacking tumor and metastasis by CD8+-T-cell, which resulted in increasing the antitumor effect and reduced metastasis.

Free Research Field

放射線治療

Academic Significance and Societal Importance of the Research Achievements

学術的意義：放射線に、ドラッグデリバリーシステムという新たな役割を与える。パーティクルを使用した放射線診断と放射線治療の同時施行を可能にする。
社会的意義：パーテイクルによる放射線治療効果増強と副作用軽減を同時に行うことで、高齢化社会の癌治療に貢献する。