2019 Fiscal Year Final Research Report

Novel treatment and experimental etiology of intestinal failure-associated liver disease following massive bowel resection

Research Project

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Project/Area Number	17K10555
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General surgery
Research Institution	Kagoshima University
Principal Investigator	MUKAI Motoi 鹿児島大学, 医歯学総合研究科, 客員研究員 (80468024)
Co-Investigator(Kenkyū-buntansha)	家入里志鹿児島大学, 医歯学域医学系, 教授 (00363359) 大西峻鹿児島大学, 鹿児島大学病院, 特任助教 (10614638) 山田和歌鹿児島大学, 鹿児島大学病院, 特任助教 (20457659) 川野孝文鹿児島大学, 医歯学総合研究科, 客員研究員 (40457651) 加治建鹿児島大学, 鹿児島大学病院, 特任教授 (50315420) 武藤充鹿児島大学, 鹿児島大学病院, 講師 (70404522) 中目和彦鹿児島大学, 鹿児島大学病院, 講師 (70448570) 町頭成郎鹿児島大学, 医歯学総合研究科, 客員研究員 (80404523) 矢野圭輔鹿児島大学, 鹿児島大学病院, 特任助教 (30757919)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	IFALD / NAFLD / ghrelin / fish oil / soybean oil
Outline of Final Research Achievements	The AST and LDH levels significantly increased, and the accumulation of lipids in the liver was observed in the short bowel syndrome Rat. The accumulation of lipids in the liver of the rats in the short bowel syndrome Rat was attenuated by the administration of ghrelin. The administration of ghrelin has a therapeutic potential for intestinal failure-associated liver disease. No significant differences in the serum liver or biliary enzymes were noted between the soybean oil and fish oil groups. The pathological findings and non-alcoholic fatty liver dysfunction score in the fish oil group did not show steatosis and were significantly lower than in the soybean oil group. An analysis soybean oil of the fatty acids profile in the both the soybean oil and fish oil groups did not indicate essential fatty acid deficiency. Fish oil lipid emulsion may have a protective role against steatosis of intestinal failure-associated liver disease without essential fatty acid deficiency.
Free Research Field	小児外科
Academic Significance and Societal Importance of the Research Achievements	短腸症候群ラットを用いた実験で広範囲腸管切除後の腸管不全関連肝障害の病理学的変化が非アルコール性肝障害と類似することがわかり、広範囲腸管切除後の腸管不全関連肝障害の実験的病態解明と新規治療法開発は成人領域で頻繁にみられる非アルコール性肝障害にも応用できるものと思われる。グレリンや魚油が広範囲腸管切除後の腸管不全関連肝障害を軽減することがわかり臨床での応用が期待できる。