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2019 Fiscal Year Final Research Report

Examination of factors disturbed ADCC activity of NK cells to the solid tumor

Research Project

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Project/Area Number 17K10613
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKawasaki Medical School

Principal Investigator

TOMIO UENO  川崎医科大学, 医学部, 教授 (70284255)

Co-Investigator(Kenkyū-buntansha) 吉村 清  国立研究開発法人国立がん研究センター, 中央病院, 医長 (30346564)
Project Period (FY) 2017-04-01 – 2020-03-31
KeywordsADCC / NK細胞 / HER2
Outline of Final Research Achievements

The aim of this study is to examine the factors which disturbed the activity of antibody-dependent cell-mediated cytotoxicity (ADCC) of natural killer T cells (NK cells) to the solid tumor and to improve the effect of antibody dependent immunotherapy. We co-incubated NK cells with either HER2+ human gastric cancer cell line (HSC-60) or HER2+ human breast cancer cell line (SK-BR-3), while adding anti-HER2 antibody. Also, we co-incubated NK cells with HER2- human breast cancer cell line (HCC1599), adding anti-HER2 antibody. We observed each ADCC activity of NK cells. We investigated the surface marker which appeared on alive cells after treatment. As a result, cells which have HER2 protein at the surface, could impair ADCC activity of NK cells.

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

固形がんに対するNK細胞浸潤能向上のための、基礎データとなる。

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Published: 2021-02-19  

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