7T-MRIを用いた「MRI陰性新皮質てんかん」の焦点可視化に関する学際的検討

2018 Fiscal Year Research-status Report

• Project/Area Number: 17K10888
• Research Institution: Niigata University
• Principal Investigator: 藤井 幸彦 新潟大学, 脳研究所, 教授 (40283014)
• Co-Investigator(Kenkyū-buntansha): 福多 真史 新潟大学, 脳研究所, 非常勤講師 (00361907) ; 大石 誠 新潟大学, 脳研究所, 准教授 (00422593) ; 松澤 等 新潟大学, 脳研究所, 准教授 (70303170) ; 柿田 明美 新潟大学, 脳研究所, 教授 (80281012)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: MRI陰性新皮質てんかん / ７テスラMRI / 機能的脳疾患 / 教育的診療研究拠点形成

Outline of Annual Research Achievements

本研究の目的は、世界トップレベルの画像研究チームや７テスラMRIを始めとした設備・施設と連携して、最新の方法論を駆使し「MRI陰性新皮質てんかん」の潜在的な焦点の可視化を目指し、その実態を把握することである。
研究初年度である平成29年度は、当初の計画通りに：1）臨床研究実施計画書を作成し、倫理委員会の承認を得た。2）西新潟中央病院を中心とした関連施設の「MRI陰性新皮質てんかん」として保存的加療を行っている非手術患者の実態を把握した。3）てんかんの焦点探索プロトコール（7T-MRI、脳磁図、256チャンネル高密度電極脳波計、SPECT、FDG-PET）の最適化を行った。
研究2年目となる平成30年度は、計画通りに：１）確立したプロトコールを実践して、西新潟中央病院を中心とした関連施設の「MRI陽性新皮質てんかん」患者にデータ収集を開始した、２）それと並行し、「MRI陰性新皮質てんかん」患者の評価を開始した。
最終年度である平成31年度（令和元年度）は、１）引き続き、「MRI陽性新皮質てんかん」患者にデータ収集を行う、２）前年度に引き続き「MRI陰性新皮質てんかん」患者の評価をおこなう、３）最終的に「MRI陰性新皮質てんかん」患者データ解析を総括する予定である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

現時点において、症例が若干少ないこと以外には、大きな問題なく計画通りに進捗している。

Strategy for Future Research Activity

研究計画の3年目である平成31年度（令和元年年度）は、前年度に継続して、確立したプロトコールを実践して、「MRI陽性新皮質てんかん」患者にデータ収集と並行し、「MRI陰性新皮質てんかん」患者の評価を行い、解析データを総括する予定である。

研究に参加する患者数が少ない場合には、関連病院等に広く患者を募る予定である。
それでも、症例の集積が十分ではない場合には、１年間の延長も検討する。

Causes of Carryover

最終年度の予定となる次年度で必要が見込まれる学会発表や論文作成のための脛腓が多くなることが見込まれるため、本年度は、当初の予定であった学会参加やそこでの情報収集に本研究費を使用せず、意図的に繰り越したため。

Research Products

• [Journal Article] Podoplanin expression and IDH-wildtype status predicts venous thromboembolism in patients with high-grade gliomas in the early postoperative period. (2019)
  • Author(s): Watanabe J, Natsumeda M, Okada M, Kanemaru Y, Tsukamoto Y, Oishi M, Kakita A, Fujii Y.
  • Journal Title: World Neurosurg. Volume: 印刷中 Pages: －
  • DOI: 10.1016/j.wneu.2019.05.049.
  • Peer Reviewed
• [Journal Article] Decreased wall shear stress at high-pressure areas predicts the rupture point in ruptured intracranial aneurysms. (2019)
  • Author(s): Suzuki T, Stapleton CJ, Koch MJ, Tanaka K, Fujimura S, Suzuki T, Yanagisawa T,Yamamoto M, Fujii Y, Murayama Y, Patel AB.
  • Journal Title: J Neurosurg. Volume: 印刷中 Pages: －
  • DOI: 10.3171/2018.12.JNS182897.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Malignant hyperthermia and cerebral venous sinus thrombosis following ventriculoperitoneal shunt in an infant with schizencephaly and COL4A1 mutation. (2019)
  • Author(s): Watanabe J, Okamoto K, Ohashi T, Natsumeda M, Hasegawa H, Oishi M, Miyatake S,Matsumoto N, Fujii Y.
  • Journal Title: World Neurosurg. Volume: 印刷中 Pages: －
  • DOI: 10.1016/j.wneu.2019.04.156.
  • Peer Reviewed
• [Journal Article] ICH Growth Individual Patient Data Meta-analysis Collaborators. Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data. (2019)
  • Author(s): Al-Shahi Salman R, Frantzias J, Lee RJ, Lyden PD, et al（著者67人中、Oish Mは14番目、Fujii Yは64番目）
  • Journal Title: Lancet Neurol. Volume: 17 Pages: 885-894
  • DOI: 10.1016/S1474-4422(18)30253-9.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Determining if Cerebrospinal Fluid Prevents Recurrence of Chronic Subdural Hematoma: A Multi-Center Prospective Randomized Clinical Trial. (2019)
  • Author(s): Toi H, Fujii Y, Iwama T, Kinouchi H, Nakase H, Nozaki K, Ohkuma H, Ohta H, Takeshima H, Tokumasu H, Yoshimoto Y, Uno M.
  • Journal Title: J Neurotrauma Volume: 36 Pages: 559-564
  • DOI: 10.1089/neu.2018.5821.
  • Peer Reviewed
• [Journal Article] Multiplex ligation-dependent probe amplification analysis is useful for detecting a copy number gain of the FGFR1 tyrosine kinase domain in dysembryoplastic neuroepithelial tumors. (2019)
  • Author(s): Matsumura N, Nobusawa S, Ito J, Kakita A, Suzuki H, Fujii Y, Fukuda M, Iwasaki M, Nakasato N, Tominaga T, Natsume A, Mikami Y, Shinojima N, Yamazaki T, Nakazato Y, Hirato J, Yokoo H.
  • Journal Title: J Neurooncol. Volume: 143 Pages: 27-33
  • DOI: 10.1007/s11060-019-03138-7.
  • Peer Reviewed
• [Journal Article] Posterior Quadrantectomy for Infant with Refractory Epilepsy:A Case Report (2019)
  • Author(s): Saito T, Oishi M, Fukuda M, Tsukamoto Y, Ohashi T, Watanabe J, Nemoto T,Kawaguchi T, Fujii Y.
  • Journal Title: No Shinkei Geka. Volume: 47 Pages: 349-356
  • DOI: 10.11477/mf.1436203943.
  • Peer Reviewed
• [Journal Article] Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice. (2019)
  • Author(s): Suzuki T, Takizawa T, Kamio Y, Qin T, Hashimoto T, Fujii Y, Murayama Y, Patel AB, Ayata C.
  • Journal Title: Stroke Volume: 50 Pages: 1216-1223
  • DOI: 10.1161/STROKEAHA.118.023928.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] EGFRvIII Is Expressed in Cellular Area of Tumor in a Subset of Glioblastoma. (2019)
  • Author(s): Nozawa T , Okada M, Natsumeda M, Eda T, Abe H, Tsukamoto Y, Okamoto K, Oishi M, Takahashi H, Fujii Y, Kakita A
  • Journal Title: Neurologia medico-chirurgica Volume: 59 Pages: 89-97
  • DOI: 10.2176/nmc.oa.2018-0078.
  • Peer Reviewed
• [Journal Article] Detecting intertrochanteric hip fractures with orthopedist-level accuracy using a deep convolutional neural network. (2019)
  • Author(s): Urakawa T, Tanaka Y, Goto S, Matsuzawa H, Watanabe K, Endo N
  • Journal Title: Skeletal Radiol. Volume: 48 Pages: 239-244
  • DOI: 10.1007/s00256-018-3016-3.
  • Peer Reviewed
• [Journal Article] The perivascular microenvironment in Epstein-Barr virus positive primary central nervous system lymphoma: The role of programmed cell death 1 and programmed cell death ligand 1. (2018)
  • Author(s): Sugita Y, Furuta T, Ohshima K, Komaki S, Miyoshi J, Morioka M, Abe H, Nozawa T, Fujii Y, Takahashi H, Kakita A.
  • Journal Title: Neuropathology Volume: 38 Pages: 125-134
  • DOI: 10.1111/neup.12435.
  • Peer Reviewed
• [Journal Article] Has acromegaly been diagnosed earlier? (2018)
  • Author(s): Ohno H, Yoneoka Y, Jinguji S, Watanabe N, Okada M, Fujii Y.
  • Journal Title: J Clin Neurosci. Volume: 48 Pages: 138-142
  • DOI: 10.1016/j.jocn.2017.10.086.
  • Peer Reviewed
• [Journal Article] Pathophysiological Characteristics Associated With Epileptogenesis in Human Hippocampal Sclerosis. (2018)
  • Author(s): Kitaura H, Shirozu H, Masuda H, Fukuda M, Fujii Y, Kakita A.
  • Journal Title: EBioMedicine Volume: 29 Pages: 38-46
  • DOI: 10.1016/j.ebiom.2018.02.013.
  • Peer Reviewed
• [Journal Article] Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-tesla magnetic resonance spectroscopy. (2018)
  • Author(s): Natsumeda M, Motohashi K, Igarashi H, Nozawa T, Abe H, Tsukamoto Y, Ogura R, OkadaM, Kobayashi T, Aoki H, Takahashi H, Kakita A, Okamoto K, Nakada T, Fujii Y
  • Journal Title: Neurosurg Rev Volume: 41 Pages: 641-647
  • DOI: 10.1007/s10143-017-0908-y.
  • Peer Reviewed
• [Journal Article] Adult Chiari Type 1 Malformation with Holocord Syringomyelia Associated with Sagittal Synostosis (2018)
  • Author(s): Sano M, Yoshimura J, Fujii Y
  • Journal Title: NMC Case Report Journal Volume: 34 Pages: 2275-2281
  • DOI: 10.1016/j.wneu.2019.05.049.
  • Peer Reviewed
• [Journal Article] High incidence of deep vein thrombosis in the perioperative period of neurosurgical patients. (2018)
  • Author(s): Natsumeda M, Uzuka T, Watanabe J, Masahumi Y, Akaiwa K, Hanzawa K, Okadda M, Oishi M, Fujii Y
  • Journal Title: World Neurosurgery Volume: 112 Pages: e103-e112
  • DOI: 10.1016/j.wneu.2017.12.139.
  • Peer Reviewed
• [Journal Article] Advances and challenges in assessing 2-hydroxyglutarate in gliomas by magnetic resonance spectroscopy: a short review. (2018)
  • Author(s): Natsumeda M, Igarashi H, Motohashi K, Suzuki Y, Ohkubo M, Okamoto K, Watanabe M, Nakada T, Fujii Y.
  • Journal Title: Neuropsychiatry (London) Volume: 8 Pages: 1831-1838
  • Peer Reviewed
• [Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration. (2018)
  • Author(s): Okada M*, Kawasaki A*, Tamada A*, Okuda S, Nozumi M, Ito Y, Kobayashi D, Yamasaki T, Yokoyama R, Shibata T, Nishina H, Yoshida Y, Fujii Y, Takeuchi K, Igarashi M(*These three authorscontributed equally.).
  • Journal Title: ISCIENCE Volume: 4 Pages: 190-203
  • DOI: 10.1016/j.isci.2018.05.019.
  • Peer Reviewed
• [Journal Article] Polysomnography as an indicator for cervicomedullary decompression to treat foramen magnum stenosis in achondroplasia. (2018)
  • Author(s): Sano M, Takahashi N, Nagasaki K, Oishi M, Yoshimura J, Fujii Y.
  • Journal Title: Child’s Nervous System Volume: 34 Pages: 2275-2281
  • DOI: 10.1007/s00381-018-3880-0.
• [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH Mutant Gliomas. (2018)
  • Author(s): Abe H, Natsumeda M, Kanemaru Y, Watanabe J, Tsukamoto Y, Okada M, Yoshimura J, Oishi M, Fujii Y.
  • Journal Title: Neurologia Medico- Chirurgica (Tokyo) Volume: 58 Pages: 290-295
  • DOI: 10.2176/nmc.ra.2018-0044.
  • Peer Reviewed
• [Journal Article] Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma. (2018)
  • Author(s): Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T.
  • Journal Title: Neurosurgery Volume: 82 Pages: 842-846
  • DOI: 10.1093/neuros/nyx314.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy. (2018)
  • Author(s): Ishiura H, Doi K, Mitsui J, Yoshimura J, Matsukawa MK, et al.（著者68人、Kakita Aは8番目）
  • Journal Title: Nat Genet. Volume: 50 Pages: 581-590
  • DOI: 10.1038/s41588-018-0067-2.
  • Peer Reviewed
• [Journal Article] Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy. (2018)
  • Author(s): Mutoh H, Kato M, Akita T, Shibata T, Wakamoto H, Ikeda H, Kitaura H, Aoto K, Nakashima M, Wang T, Ohba C, Miyatake S, Miyake N, Kakita A, Miyake K, Fukuda A, Matsumoto N, Saitsu H.
  • Journal Title: Am J Hum Genet. Volume: 102 Pages: 321-329
  • DOI: 10.1016/j.ajhg.2018.01.004.
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 苦手意識をなくそう!てんかん発作を救急で見分ける (2018)
  • Author(s): 大石 誠
  • Organizer: 研修医神経救急パワーアップセミナー（長岡市）
  • Invited
• [Presentation] 脳神経外疾患の治療戦略に役立つ凝固線溶 (2018)
  • Author(s): 藤井幸彦
  • Organizer: 第1回東毛地区有壬会（太田市）
  • Invited
• [Presentation] 最新脳外科診療 (2018)
  • Author(s): 藤井幸彦
  • Organizer: 柏崎総合医療センター院内講演（柏崎市）
  • Invited
• [Presentation] 脳梗塞の予防・治療の Update-外科的アプローチ- (2018)
  • Author(s): 藤井幸彦
  • Organizer: 新潟県医師会学術講演会（新潟市）
  • Invited
• [Presentation] Temozolomide and Notch inhibitor MRK-003 induce cell protective autophagy in malignant gliomas (2018)
  • Author(s): Natsumeda M, Fujii Y
  • Organizer: 第19回国際神経病理学会（東京都）
  • Int'l Joint Research
• [Presentation] 7-tesla MR susceptibility-weighted imaging can depict astrocytic and oligodendroglial pathology (2018)
  • Author(s): 棗田 学, 藤井幸彦
  • Organizer: 第36回日本脳腫瘍病理学会（東京都）
• [Presentation] The Growth Cone phosphoproteomics reveals an Axonal Regeneration Marker(Poster or talk) (2018)
  • Author(s): 岡田正康、藤井幸彦
  • Organizer: Cold Spring Harbor Asia Conference（淡路市）
  • Int'l Joint Research
• [Presentation] Developing models for translational research on pediatric brain tumors (2018)
  • Author(s): Natsumeda M, Fujii Y
  • Organizer: 第5回国際脳腫瘍病理シンポジウム（熱海市）
  • Int'l Joint Research / Invited
• [Presentation] The Current Situation and Prospects of Clinical High-resolution MR Imaging (Lecture for neurosurgeon) (2018)
  • Author(s): Fujii Y
  • Organizer: Seoul National University Lecture（Seoul）
  • Int'l Joint Research / Invited
• [Presentation] Mechanism of cortical motor reorganization (Lecture for gradual students ) (2018)
  • Author(s): Fujii Y
  • Organizer: Seoul National University Lecture（Seoul）
  • Int'l Joint Research / Invited