Visualization of epileptogenic foci of MRI non-lesional neocortical epilepsy patients by 7T-MRI

2021 Fiscal Year Annual Research Report

• Project/Area Number: 17K10888
• Research Institution: Niigata University
• Principal Investigator: 藤井 幸彦 新潟大学, 脳研究所, 教授 (40283014)
• Co-Investigator(Kenkyū-buntansha): 福多 真史 新潟大学, 脳研究所, 非常勤講師 (00361907) ; 大石 誠 新潟大学, 脳研究所, 准教授 (00422593) ; 松澤 等 新潟大学, 脳研究所, 非常勤講師 (70303170) ; 柿田 明美 新潟大学, 脳研究所, 教授 (80281012)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: MRI陰性新皮質てんかん / ７テスラMRI / 機能的脳疾患 / 教育的診療教育拠点形成

Outline of Annual Research Achievements

本研究の目的は、世界トップレベルの画像研究チームや７テスラMRIを始めとした設備・施設と連携して、最新の方法論を駆使し「MRI陰性新皮質てんかん」の潜在的な焦点の可視化を目指し、その実態を把握することである。
研究初年度である平成29年度は、当初の計画通りに：1）臨床研究実施計画書を作成し、倫理委員会の承認を得た。2）西新潟中央病院を中心とした関連施設の「MRI陰性新皮質てんかん」として保存的加療を行っている非手術患者の実態を把握した。3）てんかんの焦点探索プロトコール（7T-MRI、脳磁図、256チャンネル高密度電極脳波計、SPECT、FDG-PET）の最適化を行った。研究2年目となる平成30年度は、計画通りに：１）確立したプロトコールを実践して、西新潟中央病院を中心とした関連施設の「MRI陽性新皮質てんかん」患者にデータ収集を開始した、２）それと並行し、「MRI陰性新皮質てんかん」患者の評価を開始した。最終年度であった平成31年度（令和元年度）は、１）引き続き、「MRI陽性新皮質てんかん」患者にデータ収集を行い、２）前年度に引き続き「MRI陰性新皮質てんかん」患者の評価をおこない、３）最終的に「MRI陰性新皮質てんかん」患者データ解析を総括する予定であった。しかし本研究の中心的存在である7T-MRI装置が予期せず故障し、研究を相当期間休止を余儀なくされたため、研究期間延長を申請した。更に、研究再開して間もない令和２年初頭からは新型コロナウイルス感染（COVID-19）拡大に伴ない再び研究休止せざるを得なくなったため、更に１年間研究期間を延長申請した。延長最終年の令和3年度末になってもCOVID-19は収束せず、充分な研究遂行は困難であったが、最終的に「MRI陰性新皮質てんかん」の潜在的な焦点を7T-MRなどを用いて可視化することに対する新しい知見を捉えることが出来た。

Research Products

• [Journal Article] Non-contrast-enhanced silent magnetic resonance angiography for assessing cerebral aneurysms after PulseRider treatment (2022)
  • Author(s): Suzuki T, Hasegawa H, Ando K, Shibuya K, Takahashi H, Saito S, Oishi M, Fujii Y.
  • Journal Title: Jpn J Radiol Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s11604-022-01276-z
  • Peer Reviewed
• [Journal Article] JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth (2022)
  • Author(s): Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M.
  • Journal Title: Neurochem Res Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s11064-022-03580-6
  • Peer Reviewed
• [Journal Article] HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma (2022)
  • Author(s): Sasame J, Ikegaya N, Kawazu M, Natsumeda M, Hayashi T, Isoda M, Satomi K, Tomiyama A, Oshima A, Honma H, Miyake Y, Takabayashi K, Nakamura T, Ueno T, Matsushita Y, Iwashita H, Kanemaru Y, Murata H, Ryo A, Terashima K, Yamanaka S, Fujii Y, Mano H, Komori T, Ichimura K, Cahill DP, Wakimoto H, Yamamoto T, Tateishi K.
  • Journal Title: Clin Cancer Res Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1158/1078-0432.CCR-21-3622
  • Peer Reviewed
• [Journal Article] Clinicopathological risk factors for a poor prognosis of primary central nervous system lymphoma in elderly patients in the Tohoku and Niigata area: a multicenter, retrospective, cohort study of the Tohoku Brain Tumor Study Group (2022)
  • Author(s): Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Fumoto T, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
  • Journal Title: Brain Tumor Pathol Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s10014-022-00427-4
  • Peer Reviewed
• [Journal Article] Long-Term Characteristics of De Novo Bleb Formation at the Aneurysm Neck After Coil Embolization in Unruptured Cerebral Aneurysms (2022)
  • Author(s): Suzuki T, Hasegawa H, Ando K, Shibuya K, Takahashi H, Saito S, Oishi M, Fujii Y.
  • Journal Title: World Neurosurg Volume: 161 Pages: e767-e775
  • DOI: 10.1016/j.wneu.2022.02.092
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of cortical activation in human brain by flavoprotein fluorescence imaging (2022)
  • Author(s): Mitsuhashi D, Hishida R, Oishi M, Hiraishi T, Natsumeda M, Shibuki K, Fujii Y.
  • Journal Title: J Neurosurg Volume: 印刷中 Pages: 印刷中
  • DOI: 10.3171/2022.1.JNS212542
  • Peer Reviewed
• [Journal Article] Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide (2022)
  • Author(s): Eda T, Okada M, Ogura R, Tsukamoto Y, Kanemaru Y, Watanabe J, On J, Aoki H, Oishi M, Takei N, Fujii Y, Natsumeda M.
  • Journal Title: Cancers (Basel) Volume: 14 Pages: 770-770
  • DOI: 10.3390/cancers14030770
  • Peer Reviewed / Open Access
• [Journal Article] Surgical Strategy for Directional Deep Brain Stimulation (2022)
  • Author(s): Masuda H, Shirozu H, Ito Y, Fukuda M, Fujii Y.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 62 Pages: 1月12日
  • DOI: 10.2176/nmc.ra.2021-0214
  • Peer Reviewed
• [Journal Article] The Real-World status and risk factors for a poor prognosis in elderly patients with primary central nervous system malignant lymphomas: a multicenter, retrospective cohort study of the Tohoku Brain Tumor Study Group (2022)
  • Author(s): Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
  • Journal Title: Int J Clin Oncol Volume: 27 Pages: 77-94
  • DOI: 10.1007/s10147-021-02042-3
  • Peer Reviewed
• [Journal Article] Endovascular treatment of an infectious aneurysm using the selective provocative test and transcranial motor evoked potential monitoring under general anesthesia: a case report (2022)
  • Author(s): Ando K, Hiraishi T, Oishi M, Hasegawa H, Kikuchi B, Natsumeda M, Suzuki T, Saito S, Ota T, Yoshida Y, Fujii Y.
  • Journal Title: Acta Neurochir (Wien) Volume: 164 Pages: 1265-1269
  • DOI: 10.1007/s00701-021-05001-z
  • Peer Reviewed
• [Journal Article] Deep learning-based diagnosis of temporal lobe epilepsy associated with hippocampal sclerosis: An MRI study (2021)
  • Author(s): Ito Y, Fukuda M, Matsuzawa H, Masuda H, Kobayashi Y, Hasegawa N, Kitaura H, Kakita A, Fujii Y.
  • Journal Title: Epilepsy Res Volume: 178 Pages: 106815-106815
  • DOI: 10.1016/j.eplepsyres.2021.106815
  • Peer Reviewed / Open Access
• [Journal Article] Detection of 2-Hydroxyglutarate by 3.0-Tesla Magnetic Resonance Spectroscopy in Gliomas with Rare IDH Mutations: Making Sense of "False-Positive" Cases (2021)
  • Author(s): Natsumeda M, Igarashi H, Gabdulkhaev R, Takahashi H, Motohashi K, Ogura R, Watanabe J, Tsukamoto Y, Okamoto K, Kakita A, Nakada T, Fujii Y.
  • Journal Title: Diagnostics (Basel) Volume: 11 Pages: 2129-2129
  • DOI: 10.3390/diagnostics11112129
  • Peer Reviewed / Open Access
• [Journal Article] The Japan Neurosurgical Database: Statistics Update 2018 and 2019 (2021)
  • Author(s): Iihara K, Saito N, Suzuki M, Date I, Fujii Y, Houkin K, Inoue T, Iwama T, Kawamata T, Kim P, Kinouchi H, Kishima H, Kohmura E, Kurisu K (35人中5番目)
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 61 Pages: 675-710
  • DOI: 10.2176/nmc.st.2021-0254
  • Peer Reviewed
• [Journal Article] Reactive astrocytes contribute to epileptogenesis in patients with cavernous angioma (2021)
  • Author(s): Kitaura H, Hiraishi T, Itoh Y, Oishi M, Fujii Y, Fukuda M, Kakita A.
  • Journal Title: Epilepsy Res Volume: 176 Pages: 106732-106732
  • DOI: 10.1016/j.eplepsyres.2021.106732
  • Peer Reviewed / Open Access
• [Journal Article] Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study (2021)
  • Author(s): Mizobuchi Y, Nagahiro S, Kondo A, Arita K, Date I, Fujii Y, Fujimaki T, Hanaya R, Hasegawa M, Hatayama T, Inoue T, Kasuya H, Kobayashi M, Kohmura E, Matsushima T, Masuoka J, Morita A, Nishizawa S, Okayama Y, Shigeno T, Shimano H, Takeshima H, Yamakami I.
  • Journal Title: Neurosurgery Volume: 89 Pages: 557-564
  • DOI: 10.1093/neuros/nyab229
  • Peer Reviewed
• [Journal Article] Less-invasive diagnosis of disseminated epithelioid glioblastoma harboring BRAF V600E mutation by cerebrospinal fluid analysis-A case report (2021)
  • Author(s): Natsumeda M, Kanemaru Y, Kawaguchi Y, Umezu H, Kakita A, Fujii Y.
  • Journal Title: Clin Case Rep Volume: 9 Pages: e04551-e04551
  • DOI: 10.1002/ccr3.4551
  • Peer Reviewed / Open Access
• [Journal Article] Predicting BRAF V600E mutation in glioblastoma: utility of radiographic features (2021)
  • Author(s): Natsumeda M, Chang M, Gabdulkhaev R, Takahashi H, Tsukamoto Y, Kanemaru Y, Okada M, Oishi M, Okamoto K, Rodriguez FJ, Kakita A, Fujii Y, Schreck KC.
  • Journal Title: Brain Tumor Pathol Volume: 38 Pages: 228-233
  • DOI: 10.1007/s10014-021-00407-0
  • Peer Reviewed
• [Journal Article] [The Present and Future of Less-invasive Liquid Biopsy for the Diagnosis of Gliomas and Brain Tumors] (2021)
  • Author(s): Natsumeda M, On J, Watanabe J, Tsukamoto Y, Okada M, Fujii Y, Adachi J, Nishikawa R.
  • Journal Title: No Shinkei Geka Volume: 49 Pages: 527-534
  • DOI: 10.11477/mf.1436204425
  • Peer Reviewed
• [Journal Article] Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas (2021)
  • Author(s): On J, Natsumeda M, Watanabe J, Saito S, Kanemaru Y, Abe H, Tsukamoto Y, Okada M, Oishi M, Yoshimura J, Kakita A, Fujii Y.
  • Journal Title: Diagnostics (Basel) Volume: 11 Pages: 681-681
  • DOI: 10.3390/diagnostics11040681
  • Peer Reviewed / Open Access
• [Journal Article] Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates (2021)
  • Author(s): Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M.
  • Journal Title: Mol Brain Volume: 14 Pages: 66-66
  • DOI: 10.1186/s13041-021-00755-0
  • Peer Reviewed / Open Access
• [Journal Article] Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group (2021)
  • Author(s): Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Riku Y, Akagi A, Oohashi W, Shofuda T, Yoshioka E, Sato Y, Taga T, Naruke Y, Ando R, Hasegawa D, Yoshida M, Sakaida T, Okada N, Watanabe H, Ozeki M, Arakawa Y, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y.
  • Journal Title: Brain Tumor Pathol Volume: 38 Pages: 109-121
  • DOI: 10.1007/s10014-021-00396-0
  • Peer Reviewed
• [Journal Article] Delayed Bleeding of Unruptured Intracranial Aneurysms After Coil Embolization: A Retrospective Case Series (2021)
  • Author(s): Ando K, Hasegawa H, Suzuki T, Saito S, Shibuya K, Takahashi H, Oishi M, Fujii Y.
  • Journal Title: World Neurosurg Volume: 149 Pages: e135-e145
  • DOI: 10.1016/j.wneu.2021.02.061
  • Peer Reviewed / Open Access
• [Presentation] 神経科学に新たな展開をもたらす imaging treatment (2022)
  • Author(s): 藤井幸彦
  • Organizer: 第45回日本脳神経CI学会
  • Invited
• [Presentation] あすを創る人材育成：変わらなければならないもの、変わってはならないもの (2022)
  • Author(s): 藤井幸彦
  • Organizer: 第61回日本定位・機能神経外科学会
  • Invited
• [Presentation] ヒト神経細胞成長マーカーの同定 (2021)
  • Author(s): 岡田正康、金子奈穂子、山崎博幸、棗田 学、大石 誠、金村米博、澤本和延、藤井幸彦、五十嵐道弘
  • Organizer: 日本脳神経外科学会第 80 回学術総会