Treatment of chronic pain utilizing GABAergic neuron derived from iPS

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10932
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: SUZUKI Hidenori 山口大学, 大学院医学系研究科, 講師 (30393432)
• Co-Investigator(Kenkyū-buntansha): 寒竹 司 山口大学, 大学院医学系研究科, 准教授 (30464324) ; 田口 敏彦 山口大学, 大学院医学系研究科, 教授 (40179594) ; 篠田 晃 山口大学, 大学院医学系研究科, 教授 (40192108)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 脊髄損傷 / 疼痛 / 神経再生

Outline of Final Research Achievements

We revealed new synaptic formation between host spinal neurons and interneurons differentiated from grafted cells. We showed the recovery of upper limbs motor function following the recovery of cervical spinal segment. In the evaluation of sensory function, the treatment reduced allodynia and inhibitory neurons were migrated in the injured spinal cord in histological analysis. In patch clamp test, inhibitory synaptic activity were recorded between host spinal neurons and grafted interneurons. These restricted synaptic activity may effect on reducing allodynia in mice with severe spinal disorder.

Free Research Field

脊椎脊髄病

Academic Significance and Societal Importance of the Research Achievements

難治性疼痛である脊髄障害性疼痛に対し、新たな治療法の可能性を示せたことは、臨床上大きな意義があると考えている。動物実験段階から早期に前臨床試験に移行することが望まれる。