Development of new treatment and diagnostic method for ovarian cancer using biocompatible porous membrane (honeycomb films)

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Yamagata University
• Principal Investigator: OTA TSUYOSHI 山形大学, 医学部, 講師 (50375341)
• Co-Investigator(Kenkyū-buntansha): 永瀬 智 山形大学, 医学部, 教授 (00292326) ; 清野 学 山形大学, 医学部, 助教 (40594320)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 卵巣癌 / ハニカム膜 / 腫瘍増殖 / RNA sequence / 細胞骨格 / 細胞膜受容体

Outline of Final Research Achievements

Honeycomb films are uniform porous membranes. To examine the inhibitory effect of honeycomb films on tumor growth, we conducted the mice study. In mice inoculated subcutaneously with human ovarian cancer cell lines and attached honeycomb films, tumor growth was significantly inhibited as compared with the control without the attachment of honeycomb films. RNA sequence was performed on the formed tumor tissues, Gene ontology analysis showed that gene expressions related to cytoskeleton and receptor ligands were significantly suppressed in the tumor applying the honeycomb films compared to control. Collectively, the mechanism underlying the relationship between honeycomb films and tumor growth inhibition in ovarian cancer may involve abnormalities in cytoskeleton and decreases in expression of the cellular membrane receptor, thereby reducing the intracellular proliferation signaling.

Free Research Field

婦人科腫瘍

Academic Significance and Societal Importance of the Research Achievements

卵巣癌は早期発見が難しく、初回手術時は腹腔内に多数の播種病変を認め、腫瘍を完全に摘出することが困難であることが多い。ハニカム膜がin vivoにおいて卵巣癌の腫瘍形成を抑制する効果があることが明らかになった。卵巣癌において手術完遂度は治療因子の中でも重要な予後因子であり、初回可及的腫瘍減量術後の残存腫瘍にハニカム膜を貼付することで残存腫瘍の発育と浸潤・転移の抑制が可能となれば、卵巣癌患者の手術侵襲を低くし、予後を改善できる可能性がある。