Functional analysis of short chain fatty acids for eosinophilic chronic rhinosinusitis

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of Fukui
• Principal Investigator: Imoto Yoshimasa 福井大学, 学術研究院医学系部門(附属病院部), 助教 (50418703)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 短鎖脂肪酸 / フィブリン / 鼻茸

Outline of Final Research Achievements

Fibrin deposition in nasal polyps (NPs) among patients with eosinophilic chronic rhinosinusitis (ECRS) causes nasal congestion, olfactory dysfunction, and headache. Oral corticosteroid seems to be effective, however, the new strategy for ECRS are required from the point of adverse effects of oral steroid. The down regulation of tissue plasminogen activator (tPA) in nasal epithelial cells is one of the main reasons for fibrin deposition in NPs. In the present study, we demonstrated whether short chain fatty acids (SCFAs) can induce tPA from epithelial cells of not. As a result, we found that SCFAs can induce tPA from nasal epithelial cells.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

短鎖脂肪酸は、腸内細菌が発酵作用で作成したものであり、安全な物質である。本研究では、短鎖脂肪酸が受容体依存性にtPAを誘導すること見出した。この結果から、短鎖脂肪酸受容体のagonistの開発に注目し、今後好酸球性副鼻腔炎の新たな治療薬の可能性が広がることが期待できると考えられる。