Investigation for fibrovascular sacr formation of age-related macular degeneration

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11454
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyushu University
• Principal Investigator: Oshima Yuji 九州大学, 大学病院, 特別教員 (00536237)
• Co-Investigator(Kenkyū-buntansha): 園田 康平 九州大学, 医学研究院, 教授 (10294943)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 加齢黄斑変性 / 脈絡膜新生血管 / 線維性瘢痕 / 網膜萎縮

Outline of Final Research Achievements

Participation of regulatory T cell for progression of choroidal neovascularization were investigated using mouse CNV model. IL-10 regressed CNV significantly produced from regulatory T cell by suppressed IL-17 production. This inhibition pathway is an independent of VEGF.
Two hundred ninety-five AMD patients treated with anti-VEGF agent for five years were investigated retrospectively. Best corrected visual acuity was significantly deteriorated for five years. Macular atrophy, fibrovascular proliferation after 5-year treatment was suggested to be associated with basement visual acuity and FA classification, indicating that exudation into neural retina was associated with scarring in long term.

Free Research Field

眼科学

Academic Significance and Societal Importance of the Research Achievements

滲出型加齢黄斑変性は抗VEGF療法により治療可能の疾患となったが、長期的なマネジメントとして瘢痕萎縮病巣をできるだけ小さくする必要がある。今回、VEGFと独立した血管新生に関連する因子としてIL-17が考えられ、今後の治療に結びつく可能性が示唆された。また臨床的には、神経網膜内への滲出が長期の瘢痕萎縮に関連していることが明らかとなり、早期治療の有効性が示された。