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2019 Fiscal Year Final Research Report

The study of the interaction between the macrophages and the brain under the chronic postsurgical pain condition

Research Project

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Project/Area Number 17K11535
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionUniversity of Fukui

Principal Investigator

Nakai Kunihiro  福井大学, 学術研究院医学系部門(附属病院部), 准教授 (80362705)

Co-Investigator(Kenkyū-buntansha) 久保 盾貴  大阪大学, 医学系研究科, 教授 (00362707)
中江 文  大阪大学, 生命機能研究科, 特任教授(常勤) (60379170)
Project Period (FY) 2017-04-01 – 2020-03-31
Keywords術後遷延性疼痛 / マクロファージ / MRI
Outline of Final Research Achievements

MRI combined with administration of super-paramagnetic iron oxide revealed no changes of the macrophage migration into the brain both in the chronic postsurgical pain mouse model and in the lipopolysaccharide-administered mouse model.
Mice deficient in CCR2 showed attenuation of the pain-related behavior in the chronic postsurgical pain model at 4 weeks postoperatively as compared to wild type mice. Administration of the CCR2 receptor inhibitor suppressed the pain-related behavior of the chronic postsurgical pain mouse model at 4 weeks postoperatively.

Free Research Field

形成外科

Academic Significance and Societal Importance of the Research Achievements

術後遷延性疼痛の発端は手術直後の組織損傷と炎症であることは明らかである。手術に伴う組織損傷の修復では免疫細胞の中でもマクロファージがその中心的な役割を果たす。しかし、術後遷延性疼痛においてマクロファージがどのように関与するかは明らかでなかった。術後遷延性疼痛におけるマクロファージの関与を解明することは術後遷延性疼痛の予防及び治療につながり、学術的意義及び社会的意義は大きいと考えられる。

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Published: 2021-02-19  

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