Development of a novel therapy using bone marrow-derived cells for skin ulcer

2021 Fiscal Year Final Research Report

• Project/Area Number: 17K11537
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Okano Junko 滋賀医科大学, 医学部, 講師 (50447968)
• Co-Investigator(Kenkyū-buntansha): 小島 秀人 滋賀医科大学, 医学部, 教授 (00225434)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: 骨髄細胞 / 皮膚傷害 / 放射線照射

Outline of Final Research Achievements

Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.

Free Research Field

再生医学

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、局所（皮膚）で修復できないほどの傷害を受けた場合は、一時的に骨髄細胞が遊走し、表皮細胞の修復に不可欠な働きをすることがわかった。そのcriticalな因子はCCL17であるので、例えば皮膚傷害を起こした場合にCCL17を投与するという新規治療が考えられる。また、本研究では皮膚傷害を起こすために放射線照射 を用いたが、この成果は皮膚傷害は血管障害や糖尿病から発症する皮膚難治性潰瘍等にも応用でき、将来非常に有用であると考える。