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2021 Fiscal Year Final Research Report

Evaluation of abnormal cerebral blood flow for acute encephalopathy using arterial spin labeling MRI

Research Project

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Project/Area Number 17K11570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionKyoto University

Principal Investigator

Takenobu Yohei  京都大学, 医学研究科, 助教 (60641818)

Project Period (FY) 2017-04-01 – 2022-03-31
KeywordsArterial Spin Labeling / 過灌流現象 / 急性脳症 / けいれん重積
Outline of Final Research Achievements

The aim of this study is to establish methods for evaluating abnormal cerebral blood flow for acute encephalopathy using arterial spin labeling(ASL) MRI. In status epileptics, ASL-MRI adequately visualize abnormal cerebral blood flow and enables the evaluation of treatment effect. In carotid stunting, optimizing the image acquisition protocol succeeded in reducing the metallic artifacts and detecting the hyper perfusion phenomenon.

Free Research Field

神経集中治療

Academic Significance and Societal Importance of the Research Achievements

脳血流異常を呈する急性脳障害および脳血行再建術後患者において、ASL-MRIの撮像プロトコルをより短時間で安定して撮像可能なものに改良した。それを用いて、表面脳波、SPECT、MRI-ASLを反復して撮像し、治療効果判定の指標とすることができた。非侵襲的で、反復可能な本法により、重篤な脳症に対する治療成績が向上すると考えられる。

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Published: 2023-01-30  

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