The prevention and therapeutic effects of hydrogen on acute kidney injury due to ischemia -reperfusion injury

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: NEGI SHIGEO 和歌山県立医科大学, 医学部, 准教授 (20208284)
• Co-Investigator(Kenkyū-buntansha): 重松 隆 和歌山県立医科大学, 医学部, 教授 (30187348)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 急性腎障害 / 水素 / 虚血再灌流 / ラット

Outline of Final Research Achievements

The purpose of this study was to investigate the mechanism that hydrogen can prevent and ameliorate AKI in AKI due to ischemia-reperfusion injury（IRI）. IRI-induced AKI model rats were divided into two groups , a hydrogen-administered group and a non-hydrogen-administered group(control group).Before IRI, 24hours, 48 hours, 72 hours, and 7 days after IRI , creatine（Cr） level and blood urea nitrogen（BUN） level were measured. Both peak Cr and BUN values were significantly higher in the hydrogen-administered group than in the control group(24 hours). The protective effect of hydrogen against IRI-induced AKI was not observed.

Free Research Field

腎臓内科

Academic Significance and Societal Importance of the Research Achievements

水素によるAKIの予防効果や腎障害に対する軽減効果が証明できれば, 臨床において水素を用いてAKIの予防やAKIを発症した患者に対して治療薬として使用できる可能性があり, 予後改善が認められないAKI症例の予後改善につながることが期待できた。しかしながら, 今回の検討では水素によるAKIにおける腎障害の軽減効果は認められず, 水素をAKI患者の治療薬として使用することはできないと結論できる。