Investigation of aged neutrophil population in sepsis

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K11593
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Juntendo University
• Principal Investigator: Hirano Yohei 順天堂大学, 医学部, 助教 (70621895)
• Co-Investigator(Kenkyū-buntansha): 岡本 健 順天堂大学, 医学部, 教授 (40347076) ; 田中 裕 順天堂大学, 医学(系)研究科(研究院), 教授 (90252676)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 好中球 / 敗血症 / 多臓器不全 / 遊走

Outline of Final Research Achievements

The involvement of aged neutrophils population in the pathology of sepsis has already been shown previously. In this study, we have demonstrated that aged neutrophils also might be involved in the pathology of sepsis in humans. It was confirmed that the expression of CXCR4, which is a marker of aged neutrophils, was increased in septic patients compared with healthy subjects. In addition, the percentage of aged neutrophils population in the whole blood of septic patients and the severity score (SOFA score) showed a significant inverse correlation. These observations indicate that aged neutrophils might be typical phenotype during transmigration of neutrophils into inflamed tissues.

Free Research Field

救急集中治療

Academic Significance and Societal Importance of the Research Achievements

敗血症の死亡率は依然として高く、新たな治療戦略の開発は急務である。我々はヒトにおいて高齢好中球が敗血症病態に関与している可能性を証明した。敗血症の重症度と血中高齢好中球割合は逆相関関係があったという観察結果に加え、高齢好中球が組織浸潤における好中球の主要なサブタイプである可能性があるという結果は、将来的には、高齢好中球の遊走能を調節することによる敗血症の重篤な組織障害を是正するという新たな治療戦略につながる可能性を見出した。