2019 Fiscal Year Final Research Report
A study for the mechanism of exercise therapy to promote the motor functional recovery after brain injury.
| Project/Area Number |
17K13069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 脳損傷 / 運動 / 運動機能障害 / 運動機能回復 / 動作分析 / 代謝 / 皮質脊髄路 / 遺伝子 |
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| Outline of Final Research Achievements |
Exercise therapy is one of the methods for motor functional recovery with brain injury patients. The purpose of this study was to clarify the mechanism of motor function recovery. It was kinematically revealed that the exercise promoted the changes in motor function on the paretic side. In addition, physiological and morphological changes in the nerves and skeletal muscles were also detected. It was found that exercise induces not only changes in neural networks but also changes in skeletal muscles. From this reason, it was suggested that exercise leads to recovery of motor function.
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| Free Research Field |
リハビリテーション医学、神経生理学、理学療法学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、脳損傷患者の運動機能障害からの回復と社会復帰に向けた基盤研究である。本研究では、モデル動物を用いて定量化された運動課題を行うことで、運動機能の変化を運動学的に現すことができた。さらに運動学的に表現された運動機能を司る神経および骨格筋の変化も明らかにすることができた。これらの結果は、運動療法の運動機能を回復させるメカニズムの解明に寄与するとともに動物からヒトへの橋渡し研究にも波及することが期待される意義のある結果である。
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