2022 Fiscal Year Final Research Report
Relationship between post-stroke depression improvement by rTMS and neuroplasticity-related biomarkers
| Project/Area Number |
17K13070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nihon University (2022)
Jikei University School of Medicine (2017-2019, 2021) |
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Principal Investigator |
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| Project Period (FY) |
2021-03-01 – 2023-03-31
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| Keywords | 反復経頭蓋磁気刺激治療 / 神経可塑性 / 脳卒中後うつ |
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| Outline of Final Research Achievements |
The Beck Depression Inventory indicated improvement of depressive symptoms in the stroke patients by rTMS.
In this study, serum levels of NMDAR-related amino acids and kynurenine pathway-related biomarkers were measured before and after treatment. Serum D-serine level decreased and L-serine level increased after rTMS. Serum tryptophan level decreased in the group receiving rTMS to the right brain and increased in the group receiving rTMS to the left brain. Serum kynurenine/tryptophan ratio was elevated in the group receiving rTMS to the right brain.
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| Free Research Field |
ニューロリハビリテーション
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| Academic Significance and Societal Importance of the Research Achievements |
脳卒中後うつ状態の客観的評価に神経可塑性関連物質の血清濃度がバイオマーカーとして有用である可能性が示唆された。
本研究をさらに発展させると、脳卒中後うつ状態を早期より診断可能となり、また、その診断精度も向上させることができる可能性がある。また、薬物治療や rTMS 治療はもちろん、今後の脳卒中後うつに対する新たな治療的アプローチに関する介入試験を行う際にも、神経可塑性関連物質の血清濃度を治療前後で継時的に測定することによって、客観的な治療効果判定を行うことができるようになることが期待される。
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