2018 Fiscal Year Final Research Report
Control of TGF-beta related protein based on selective photooxygenation
| Project/Area Number |
17K13260
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Research Collaborator |
HAYASHI Yoshio
TAKAYAMA Kentaro
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | 光酸素化 / 触媒 / ペプチド / マイオスタチン |
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| Outline of Final Research Achievements |
Myostatin, one of the transforming growth factor-beta (TGF-beta) superfamily proteins, negatively regulates a growth of muscle mass. In this study, a conjugate which is composed of myostatin-binding peptide and photo-oxygenation catalyst was developed, and the conjugate successfully induced myostatin-selective photo-oxygenation. Moreover, the oxygenation drastically inhibited the activity of myostatin.
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| Free Research Field |
ペプチド化学、ケミカルバイオロジー、創薬化学
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| Academic Significance and Societal Importance of the Research Achievements |
TGF-β (transforming growth factor-β：トランスフォーミング増殖因子β)スーパーファミリーに属するマイオスタチンは、筋肉の増殖を抑制する活性をもつ。本研究では、マイオスタチンを選択的に光酸素化し、不活化する分子を創製した。このマイオスタチン阻害法は、筋肉量を増大し、筋ジストロフィーや老年性筋萎縮等の筋萎縮性疾患に対する新しい治療法になる可能性がある。
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