Is hemophagocytic histiocytic Sarcoma a malignant tumor? Approach from the failure of Macrophage self-recognition

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K15381
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Kagoshima University
• Principal Investigator: Takahashi Masashi 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (40750419)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 組織球肉腫 / 犬 / マクロファージ / cd47 / SIRPα

Outline of Final Research Achievements

hemophagocytic syndrome in dogs has similar characteristics to hemophagocytic syndrome in human. It has been reported that disruption of the phagocytosis-suppressing signal by the CD47-SIRPα signal is involved in the onset of hemophagocytic syndrome. To clarify the pathophysiology of hemophagocytic syndrome in dogs, we planned a basic study on CD47-SIRPα signal in dogs. The expression distribution of CD47 and SIRPα in each blood cell of a healthy dog was evaluated by flow cytometry and revealed to be similar to the expression in human blood cells, respectively. Furthermore, we evaluate the expression of SIRPα in the spleen by immunohistochemistry.

Free Research Field

獣医学

Academic Significance and Societal Importance of the Research Achievements

本研究より犬におけるCD47およびSIRPαの発現に関する基礎的情報を得ることができた。今回得られた知見をもとに、犬の血球貪食性組織球肉腫の病態を明らかにするための研究へとすすめることができる。これまで悪性腫瘍と考えられている本疾患がマクロファージの貪食能の異常による疾患であることを評価するための研究へとつながり、これまでとは異なる治療アプローチの発見に有用となる可能性が考えられた。