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2018 Fiscal Year Final Research Report

Drug discovery and neurochemical researches about T-type calcium channel in neurogenesis.

Research Project

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Project/Area Number 17K15456
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pharmacology in pharmacy
Research InstitutionTohoku University

Principal Investigator

Yabuki Yasushi  東北大学, 薬学研究科, 助教 (70756121)

Research Collaborator Xu Jing  
Project Period (FY) 2017-04-01 – 2019-03-31
KeywordsT 型カルシウムチャネル / 神経新生
Outline of Final Research Achievements

Number of depressive patients is over million in Japan, and it is serious social problem that depressive patients may account for 60% of suicides. We succeeded to develop T-type calcium channel enhancer. This compound improved depressive-like behaviors in olfactory-bulbectomized (OBX) mice. Whereas depressive-like behaviors are closely associated with hippocampal adult neurogenesis, T-type calcium channel enhancer could restore impaired hippocampal neurogenesis in OBX mice. In addition, T-type calcium channel enhancer enhanced monoamine releases in the mouse hippocampus, which have important role in depression. Finally, we observed impaired neurogenesis in the T-type calcium channel gene knock out mouse hippocampus. Taken together, we suggest that T-type calcium channel may have an important role in adult neurogenesis and brain homeostasis.

Free Research Field

神経薬理学

Academic Significance and Societal Importance of the Research Achievements

既存の抗うつ薬はモノアミントランスポーターを阻害し、セロトニンやノルアドレナリンなどのモノアミンを増加させることで抗うつ効果を示す。しかしながら、抗うつ効果が得られるまでに時間がかかること、治療抵抗性うつ病患者の増加していることから新規作用機序の治療薬開発が求められている。また、T 型カルシウムチャネル賦活化薬の開発は世界初であり、研究のオリジナル性および独創性は極めて高いと考えられる。さらに、T 型カルシウムチャネルの脳高次機能については未だ不明な点が多く、神経新生やうつ病との関連が明らかになれば神経科学の発展と新規抗うつ薬の開発に大きく貢献できると考えられる。

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Published: 2020-03-30  

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