Sugar chain targeting symmetrical boronic acid derivatives

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K15486
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Fukuoka University
• Principal Investigator: Furutachi Makoto 福岡大学, 薬学部, 助教 (30759931)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 創薬 / 生物活性 / 糖鎖 / C2対称 / ボロン酸

Outline of Final Research Achievements

Biological activity of synthesized compounds was evaluated and some compounds showed antibacterial, antiviral, and cytotoxic activities. The anticancer activity of compounds that showed cytotoxic activity was evaluated using human brain cancer cells and human head and neck cancer cells. All of the synthesized compounds showed lower anticancer activity toward human brain cancer cells than that of the positive control drug cisplatin, but one synthesized compound showed higher anticancer activity toward human head and neck cancer cells than that of cisplatin.

Free Research Field

創薬化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、多剤耐性菌や多剤耐性ウイルスの出現により需要の高まる、新たな抗菌薬および抗ウイルス薬の創製へと繋がる可能性のある化合物を創出した。また、社会的要請の大きい、新たな抗悪性腫瘍薬の創製へと繋がる可能性のある化合物を探索し、既存の抗悪性腫瘍薬シスプラチンよりも抗腫瘍活性の強い化合物を創出した。