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2018 Fiscal Year Final Research Report

The mechanism of gastric MALT lymphoma formation after H. suis infection via the activation of CXCL13

Research Project

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Project/Area Number 17K15684
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionHokkaido University

Principal Investigator

YAMAMOTO KOJI  北海道大学, 医学研究院, 特任助教 (70608322)

Project Period (FY) 2017-04-01 – 2019-03-31
KeywordsHelicobacter suis / 胃MALTリンパ腫 / 濾胞性樹状細胞 / インターフェロンγ / インターフェロンγ受容体 / CXCL13
Outline of Final Research Achievements

Helicobacter suis (H. suis) infects various animals especially in pigs and humans. Interestingly, it has been reported that H. suis infection is able to induce the formation of gastric mucosa associated lymphoid tissue (MALT) lymphomas in 100% of mice. In addition, we recently reported that the formation of gastric lymphoid follicles following H. suis infection is dependence on the high expression of interferon-γ (IFN-γ) and CXC chemokine ligand 13 (CXCL13). However, the relationship between the expression of IFN-γ and the production of CXCL13 in the stomach of H. suis infected mice remains unclear.
In this study, we showed that the expression of IFN-γ interacting with IFNGR on FDC produces CXCL13 through the activation of IkB-α-NF--B2 pathway.These results suggest that the interaction between IFN-γ and IFNGR is important for CXCL13 production from FDCs and is associated with gastric lymph follicle formation after H.suis infection.

Free Research Field

感染症と粘膜免疫学

Academic Significance and Societal Importance of the Research Achievements

ヘリコバクタースイス (H. suis)は、マウス胃粘膜に感染するとCXCL13と呼ばれる遺伝子が高発現しており、抗CXCL13抗体を用いると胃MALTリンパ腫発症を有意に抑制させることが明らかとなっている。よって、H. suis感染後のCXCL13の発現が胃MALTリンパ腫発症に関与していると考えられる。そこで本研究課題では、H. suis感染からどのようなメカニズムでCXCL13を産生させ、どのように胃MALTリンパ腫を発症させれいるかの解明を目的とする。これらの詳細を明らかにすることで胃MALTリンパ腫発症を抑制させる新規治療法の開発が期待される。

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Published: 2020-03-30  

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