2022 Fiscal Year Final Research Report
Elucidation of the recovery mechanism of endogenous analgesic pathways weakened by neuropathic pain
| Project/Area Number |
17K15787
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Keywords | 内因性鎮痛 / trkBagonist |
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| Outline of Final Research Achievements |
The study was conducted with 7,8-DHF (Dihydroxyflavone), an agonist of the receptor (trkB) on which BDNF acts, and it was confirmed that endogenous analgesia was restored by administration of 7,8-DHF.
In the future, α2A receptor antagonists will be used to confirm whether the same results as 7,8-DHF administration will be obtained, and to support the involvement of α2A receptor downregulation and AMPA receptor activation in NSIA recovery. , We planned to examine the expression of each receptor in the locus coeruleus by immunostaining method using each receptor antibody, and to investigate the effect on NSIA, but it was expected because of the busy clinical work due to the corona crisis. No research results were obtained.
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| Free Research Field |
麻酔神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
trkB agonistにより内因性鎮痛経路は回復した。さらにα2A受容体やAMPA受容体が内因性鎮痛にどのように関与しているかが解明されれば、神経障害性疼痛治療の新たなアプローチとして確立されることとなり、社会的に重要な意義をもつと考えられる。今後さらに研究を続け、内因性鎮痛経路の解明を進めていく。
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