Comparison of characteristics, prognosis, and risk factors in HFpEF between Japan and United States

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K15821
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tohoku University
• Principal Investigator: Nochioka Kotaro 東北大学, 大学病院, 特任准教授 (20598411)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 左室駆主率が保持された心不全 / 予後因子 / 国際比較

Outline of Final Research Achievements

Heart failure with preserved ejection fraction is a disorder with poor prognosis. Using the data from CHART-2 Study in Japan and TOPCAT in USA, we compared the baseline characteristics and prognostic factors. We found that HFpEF patients in Japan and USA showed similarity with elder and higher prevalence of women. However, medications were different with higher use of beta blocker and diuretics in the HFpEF patients in USA. We also identified age, albumin, anemia, body mass index, BNP and BUN were associated with poor prognosis in both Japan and USA HFpEF patients.

Free Research Field

心不全

Academic Significance and Societal Importance of the Research Achievements

いまだ確立されていない左室駆出率が保持された心不全の特徴を国際比較することにより、病気の理解や内服治療の似ている点、異なる点の理解が進んだ。また、年齢や貧血、体格、栄養状態といった心臓外で全身状態を表す指標が予後不良と関連していることが示された。今後は貧血や栄養状態の改善を行うことが、このタイプの心不全に有効か今後検討が必要と思われた。