2021 Fiscal Year Final Research Report
The large-scale cohort study on life-style related risk factors for CKD
Project/Area Number |
17K15850
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Niigata University |
Principal Investigator |
Kabasawa Keiko 新潟大学, 医歯学総合研究科, 特任助教 (70529726)
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Project Period (FY) |
2018-02-28 – 2022-03-31
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Keywords | 慢性腎臓病 / コホート研究 / 生活習慣 |
Outline of Final Research Achievements |
Using the framework of an ongoing large-scale prospective cohort study (the Uonuma cohort study, 40 years and older, N = 39,764), this study aimed to collect the case of chronic kidney disease (CKD) and identify its lifestyle-related risk factors. Among respondents to the 5-year follow-up survey (n = 30,495), 2.8% self-reported new onset of CKD during the 5-year follow-up period. Using the baseline data, we found the associations of dietary acid load and sodium-to-potassium ratio with albuminuria, and muscle strength (grip strength) with kidney function.
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Free Research Field |
疫学
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Academic Significance and Societal Importance of the Research Achievements |
CKDは糖尿病や高血圧などの生活習慣病が主なリスク因子であり、進行すると末期腎不全だけでなく、心血管病の発症リスクを高める。本研究では、大規模な一般地域住民コホートを用い、5年後追跡調査を完了するとともに、ベースライン調査からCKDの生活習慣関連因子を明らかにすることができた。本研究から発信されるエビデンスは日本人のCKD一次予防戦略のための基礎資料となる。
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