• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Final Research Report

Insight into the Molecular Mechanisms of Heart-Gut Axis in the Pathophysiology of Heart Failure

Research Project

  • PDF
Project/Area Number 17K15989
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionThe Institute for Adult Diseases Asahi Life Foundation

Principal Investigator

Kamo Takehiro  公益財団法人朝日生命成人病研究所, 循環器科, 部長 (10722556)

Research Collaborator Yao Takako  
Project Period (FY) 2017-04-01 – 2019-03-31
Keywords心疾患 / 腸上皮バリア / 腸内細菌
Outline of Final Research Achievements

The aim of this research is to explore the link between the heart and the gut and to clarify the functional roles of the gut and the gut microbiota in the pathophysiology of heart failure. This research focuses on the following subjects.
1) Insight into the role of gut epithelial barrier function in heart failure. I have found that expression levels of antimicrobial peptides were decreased in the gut epithelium of mice with heart failure.
2) Insight into the functional role of gut microbiota in heart failure. I recently showed that heart failure is associated with gut microbiota dysbiosis through 16S ribosomal RNA gene sequencing of fecal samples from patients with heart failure. Furthermore, I have discovered that depletion of gut microbiota attenuates cardiac hypertrophy in mice with heart failure.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

本研究によって腸および腸内細菌叢と心不全との関連性が明らかになれば、心不全の病態研究にブレイクスルーがもたらされ、さらに腸上皮バリアおよび腸内細菌叢への介入による新たな心不全治療開発の基盤構築につながることが期待される。すなわち、食事や薬剤などにより腸上皮バリアおよび腸内細菌叢を制御することができれば、これまでの薬物治療とは全く異なるアプローチによる心不全治療が確立されることになる。

URL: 

Published: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi