Role of Polycomb potentiates in acute kidney disease

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16103
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: Ichikawa Daisuke 聖マリアンナ医科大学, 医学部, 講師 (70750157)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 急性腎障害 / ポリコームグループタンパク質 / SCMH1

Outline of Final Research Achievements

Frequency of onset of iatrogenic acute kidney injury (AKI) is increasing under development of medical technology in as aging society. However, such a AKI has few curative treatments. The aim of this study was to reveal a role of polycomb group protein (Bmi1 and SCMH1) under hypoxia which is a main cause of iatrogenic AKI. Because proximal tubular cells are principle target for the AKI, human proximal tubular cells (HK2 cells) were used. Down-regulation of SCMH1 by siRNA for SCMH1 induced increase in cytotoxicity and decrease in cell survival rate. However, such a result was not found by down-regulation of Bmi1 by siRNA for Bmi1.The SCMH1 expressed in the proximal tubule may have a protective effect against hypoxia.

Free Research Field

腎臓病学

Academic Significance and Societal Importance of the Research Achievements

高齢者の増加、医療技術の進歩により、医原性の急性腎障害(AKI)の発症頻度が、世界的に増加しているものの、その有効な治療法がないため、ポリコームグループタンパク質（PRC1構成蛋白 Bmi1およびSCMH1)に着目し、その細胞保護作用の有無を検討した。その結果、SCMH1が、腎保護的に作用する事が明らかになった。SCMH1の発現増強は、AKI治療に有効である可能性があり、さらなる検討を行う。