Significance of Leptin and BDNF in Sarcopenia and Frailty

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K16169
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Osaka City University
• Principal Investigator: Kurajoh Masafumi 大阪市立大学, 大学院医学研究科, 講師 (90598319)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: レプチン / サルコぺニア / フレイル

Outline of Final Research Achievements

Animal studies have shown that leptin, secreted from adipose tissue, contributes to the promotion of bone resorption and suppression of bone formation through activation of the sympathetic nervous system. However, the relationship between leptin and sarcopenia/frailty has not been fully elucidated. We reported that plasma leptin concentrations are associated with radial cortical bone thickness in type 2 diabetic patients, independent of various background factors. These results indicate that leptin is associated with sarcopenia and frailty.

Free Research Field

代謝内分泌

Academic Significance and Societal Importance of the Research Achievements

肥満患者におけるサルコペニア・フレイルの発症メカニズムは明らかにされていなかったが、本研究により脂肪細胞から分泌されるレプチンの関与が明らかとなった。本研究により、肥満患者における減量をかいしたレプチン抵抗性の改善が、サルコペニア・フレイルの進展予防につながることを明らかにした。