Change in brain glucose metabolism and default mode network during the course of recovery in anorexia nervosa

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K16374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Kurita Daisuke 浜松医科大学, 医学部附属病院, 助教 (80585307)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 神経性やせ症 / anorexia nervosa / glucose metabolism / default mode network

Outline of Final Research Achievements

Functional connectivity map of the healthy subject was analyzed using SPM12. According to the previous report, we computed for subject's functional connectivity map representing the default network by correlating the mean signal time course from a spherical seed region within the posterior cingulate cortex (PCC) with the time courses of other brain region, using Pearson's product moment correlation. The activation in PCC region were correlated temporally with medial frontal cortex, temporal pole, and temporo-parietal junction, in which DMN were indicated. Longitudinal change in brain glucose metabolism and default mode network during the course of recovery in anorexia nervosa comparing healthy control is now under investigation.

Free Research Field

摂食障害

Academic Significance and Societal Importance of the Research Achievements

超低体重の神経性やせ症群では安静時fMRIにおけるデフォルトモードネットワークの障害や18F-FDG PETによる糖代謝の障害が健常群と逸脱していることが予測される。栄養状態回復にともなう脳画像指標と臨床症状の変化は身体状態に付随する状態依存性の指標(state marker)と考えられるが、体重が回復後もなお健常群から逸脱する脳画像指標は神経性やせ症の素因を反映する指標(trait marker)と考えられる。これら画像所見から得られる生物学的指標を比較検討することで、ANの病態や症状改善および難治性の脳内メカニズムを明らかにできると期待される。