Creation of in vivo dormant human lung adenocarcinoma model

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K16615
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Jichi Medical University
• Principal Investigator: Shibano Tomoki 自治医科大学, 医学部, 助教 (10648900)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 肺癌 / 転移 / 微小環境

Outline of Final Research Achievements

Since prognosis of lung cancer has improved in the past few decades, the opportunity to encounter late recurrence has also increased. Dormancy, a phenomenon that cancers achieve resistant to treatment and sleeps inside the body for few years had been frequently discussed in cancers with slow progression; ie. breast cancers or prostatic cancers, but not for lung cancers. In this study, we discovered that some human adenocarcinoma cell lines express dormant characteristics in vivo and in vitro, suggesting dormancy may also exists in lung cancers.

Free Research Field

肺癌

Academic Significance and Societal Importance of the Research Achievements

肺癌のdormancyに関する研究は今後の肺がん患者の予後改善のためには必要不可欠であるが、進行の早い肺癌では適切なdormancyモデルは存在しない。本研究により得られたヒト肺癌細胞dormancyモデルを今後さらに解析し、確立することで肺がん研究のさらなる発展に繋がると考えている。