2018 Fiscal Year Final Research Report
The elucidation of molecular mechanism of chromosomal translocation in prostate cancer and application to new treatment
| Project/Area Number |
17K16787
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Research Collaborator |
Kawauchi Akihiro
Agata Yasutoshi
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | 前立腺癌 / TMPRSS2-ERG転座 |
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| Outline of Final Research Achievements |
Translocation of the androgen response gene TMPRSS2 and the transcription factor ERG gene in prostate cancer is observed in about 50% of prostate cancer cases and is a prognostic factor. In this study, we examined whether or not access to the TMPRSS2 / ERG gene occurs in androgen receptor foci. The combination of immunostaining and FISH was used to examine the relationship, but the approach of the TMPRSS2 / ERG genes was not observed with androgen, nor was the approach to AR foci observed. We also investigated whether BRD4, which works in concert with AR, affects translocation, but there was no change in the distance between the two genes, even with BRD4 inhibitor JQ1. In the future, we will examine the relationship with Ying Yang 1 (YY1) as a factor that binds to AR and induces chromosome looping.
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| Free Research Field |
泌尿器癌
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により転座の新たなメカニズムを解明できれば、転座の抑制に応用ができる。前立腺癌は多発性かつ、不均一な組織集団であり、ひとつの前立腺内においても転座の有無が混在している。転座が起こっていない領域において転座を抑制することは、前立腺癌、特にCRPC治療において新たな治療法の開発に寄与することが期待される。
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