2018 Fiscal Year Final Research Report
Biological function of LSR in ovarian cancer
| Project/Area Number |
17K16882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | 卵巣癌 / 脂質代謝 / LSR |
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| Outline of Final Research Achievements |
LSR is a membrane protein which takes in lipid molecules. When we administrated some fatty acids to LSR-positive ovarian cancer cell, Elaidic acid which is a one of the trans-fatty acid promoted accumulation of lipid droplets and promoted ATP production and cell proliferation. Moreover, Elaidic acid promoted cell migration of LSR-positive cells. These resuts suggest that LSR contributes ovarian cancer spread. Finally our newly developed anti-LSR antibody inhibited theses processes.
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| Free Research Field |
婦人科腫瘍
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| Academic Significance and Societal Importance of the Research Achievements |
今回LSRが脂肪酸の一種であるトランス脂肪酸を取り込み癌細胞の増殖と遊走に貢献することを証明した。また抗LSR抗体が卵巣癌の進展に重要な要素である増殖と遊走を阻害することから、抗LSR抗体は新規の卵巣癌治療薬として可能性を示した。
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