Widespread injury of intestinal serosa with type I collagenase promote colonization of transplanted enteric neural stem cells

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K17008
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Kanazawa Medical University
• Principal Investigator: YASUI Yoshitomo 金沢医科大学, 医学部, 助教 (10595325)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 細胞外マトリクス / 腸管神経細胞

Outline of Final Research Achievements

Hirschsprung’s disease (HSCR) causes abdominal distension and survival requires surgical excision of aganglionic bowel. However, after surgery, enterocolitis and fecal incontinence commonly occurs. Therefore, New strategies are needed to enhance bowel colonization by enteric neuron precursors and to reduce HSCR occurrence. In this study we demonstrated that injury of serosa with type I collagenase promote colonization of transplanted enteric neural crest derived Cells.

Free Research Field

小児外科学

Academic Significance and Societal Importance of the Research Achievements

我々の研究結果は、I型コラゲナーゼを処理したレシピエントの大腸が、未治療の大腸よりも腸管神経系をより迅速に展開したことを示した。ドナーの神経幹細胞を受容可能な結腸にするこれらの発見は、細胞療法の現在の戦略を前進させることに役立つ。