2019 Fiscal Year Final Research Report
To clarify the Effects of T-cells on Healing of Tooth Extraction Socket and Osseointegration
Project/Area Number |
17K17212
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Ohu University (2018-2019) Nagasaki University (2017) |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Keywords | T細胞 / 骨代謝調節 / オッセオインテグレーション |
Outline of Final Research Achievements |
The purpose of this study was made to comfirm a molecular basis for new therapies focused on T cell-related molecules by investigating T cell-related molecules in the extraction socket healing and osseointegration on bone immunological studies. If this study becomes clear, it may be guidelines for the development of new therapies that induced to early healing of the extraction socket and osseointegration establishment. However, the results of the preparation of Th17-activity model rat, which is the basis of this study, showed no changes protein levels of acute phase in serum and inflammatory diseases that could be considered as indicators of Th17-activity. Therefore, it was difficult to establish a model rat and useful experimental results could not be obtained.
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Free Research Field |
歯学
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Academic Significance and Societal Importance of the Research Achievements |
IL-17に関する研究成果を基盤として,侵襲的歯科治療が顎骨のT細胞関連分子に与える影響を明らかにすることにより,T細胞を基軸とした抜歯やインプラント治療に関わる新規治療法の分子生物学的基盤の構築に貢献でき,本研究が明らかとなれば,抜歯窩の治癒とオッセオインテグレーションにおいてT細胞関連分子の制御による新規治療法の分子生物学的基盤を構築するばかりか,抜歯窩の治癒やオッセオインテグレーションの獲得を早期に導く新規治療法開発の指標になり得ると考えられる.
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